Subsequently, treatments were prescribed by the doctor. Hecker M. Efficacy and tolerance of Ivy extract (Prospan®) in patients suffering from respiratory tract diseases. In fact, a 2012 study involving 268 children, 0 to 12 years old, discovered that 14 days of treatment with ivy leaf extract (in the form of a cough syrup) was a safe and effective treatment for children with a cough. The physician selected the patients for whom the diagnosis enabled them to be included into the study and to be treated with the abovementioned prescriptions. In addition, approximately 50% of patients with acute bronchitis report the production of purulent sputum [2]. However, you still need to take ACTIVOX Ivy syrup carefully to get the best results from it. The tolerability of the herbal medication was very good. Nat Med 1999;14:28–33. [12] in children and adults. Ivy leaf is also gaining popularity as a natural cough syrup for kids. Acetylcysteine (ACC) was chosen as comparator drug (common mono preparations). * The daily self-assessment of patient’s documentation for days 1–6 was done with 5-stage-scored questions except for number of coughing fits and frequency of wake ups at night which have a 4-stage-score. Criteria for exclusion of the documentation were as follows: known hypersensitivity to the active ingredients, treatment with the medications in the last two weeks before study entry, participation in another trial in the same time, and legal incapacity. This medicine is available without prescription. Acetylcysteine (ACC) was chosen as comparator drug (common mono preparations). Non-drowsy, sugar-free, alcohol-free, no added coloring with pleasant natural blackcurrant flavor. The current noninterventional study was performed in 118 patients using EA 575® and 21 patients using ACC for the treatment of acute bronchitis. Product: Cofif Syrup. Results of this multicenter study proved the advantage of the treatment of ivy leaves in acute bronchitis that is evidently comparable with acetylcysteine. Probably the drug-related AEs (adverse drug reactions (ADRs)) were in accordance with the known side-effect profile of ivy preparations. https://www.blackmores.com.au/.../ivy-leaf-for-cough-relief Data from a large clinical trial revealed that the median duration of cough from acute bronchitis due to all causes was 18 days [2]. Relevant concomitant diseases and treatments. All tests were performed using IBM SPSS for Windows software, version 25. In Europe, the prevalence for cough is 33% in the population group aged 18 to 48 years [10]. Open trials to assess aspects of safety and efficacy of a combined herbal cough syrup with Ivy and Thyme. Regarding concomitant diseases, 44.1% of the subjects in the EA 575® group suffered from concomitant diseases and 38.1% in the ACC group. Average weight was 66.1 kg in the EA 575® group and 71.7 kg in the ACC group. This limitation can be addressed in further interventional studies with an randomized study design. The physician was totally free in his or her decisions of therapy. Acute bronchitis is a clinical term implying a self-limited inflammation of the large airways of the lung that is characterized by cough without pneumonia. containing ivy leaf extract. – Non GMO Sustainably Sourced Vegetarian, Zarbee's Naturals Baby Cough Syrup with Agave & Thyme, Natural Cherry Flavor, 2 Ounce Bottle, Robitussin Naturals Cough Relief & Immune Health Syrup 8.3oz with Honey, Ivy Leaf & Zinc. No statistical significance was seen between the treatments. Objective. Physicians judged the tolerability as “very good” and “good” with 99.1% for the EA 575® group and 95.2% for the ACC group. Granulate: for 12 years and older and adults, three times daily, one sachet 200 mg, and for children up to 12 years, three times daily, one sachet 100 mg. Effervescent tablet: for 12 years and older and adults, one time daily, one tablet 600 mg. Significant improvement in each of the symptoms from entry visit to final visit (, Assessment of the Efficacy and Safety of Ivy Leaf (, Max Zeller Söhne AG, Seeblickstrasse 4, Romanshorn 8590, Switzerland, CONSULTING HMP, Brückstrasse 11, Weinheim 69469, Germany, Landarztpraxis Sevelen, Velturrietstrasse 5, Sevelen 9475, Switzerland, Evidence-Based Complementary and Alternative Medicine, Acute bronchitis, caused by bacterial infection (ICD-10: J20.0-J20.2) [, Acute bronchitis, caused by viral infection (ICD-10: J20.3-J20.7), Other acute inflammation of the respiratory tract accompanied with cough, The average duration of symptoms at entry visit (days), Concomitant infections and other diseases, None (N; % of patient within treatment group), R. P. Wenzel and A. Formulations similar to Coferb have been recognized by international clinical trials endorsing safety and efficacy of the product. There were 4 different consent forms used in the study depending on the age of the subjects: one consent form for adult subjects, one form for subjects ranging between 14 and 18 years old (signed by the subjects), one form for subjects between ages 11 and 13 years who can already read the document by themselves (signed by the parents), and one form for parents of subjects between 6 and 11 years (signed by parents). Your recently viewed items and featured recommendations, Select the department you want to search in, All customers get FREE Shipping on orders over $25 shipped by Amazon, Try our simple and soothing honey cough syrup, Zarbee's Naturals Cough Syrup + Mucus Nighttime with Melatonin, Natural Honey Lemon Flavor, 8 Ounce Bottle, Zarbee's Naturals Cough Syrup* + Mucus, Natural Honey Lemon Flavor, 8 Ounce Bottle, Zarbee's Naturals 96% Honey Cough Soothers + Mucus with Ivy Leaf Extract, Lemon Menthol Flavor, 14 Count. Esther Kruttschnitt, Tankred Wegener, Catherine Zahner, Silke Henzen-Bücking, "Assessment of the Efficacy and Safety of Ivy Leaf (Hedera helix) Cough Syrup Compared with Acetylcysteine in Adults and Children with Acute Bronchitis", Evidence-Based Complementary and Alternative Medicine, vol. Coferb Cough Syrup. Average values of physician’s evaluation comparing the final visit with the entry visit. You may need to read it … Further, the use of these agents is not recommended as a general practice according to present guidelines [21]. At entry visit, all clinical assessments including coughing fits, sputum, dyspnoea, rales, severity of the diseases, and coughing quality were rated with moderate intensity in both groups. 13 children belonged to the class group 6–11 years with an average height of 136.0 cm and an average weight of 32.3 kg. During the study, two unwanted events occurred. It relieves cough naturally and makes breathing easy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Product: Cofif Plus Syrup. It is an efficient and natural remedy for adult and children. Early research shows that taking a cough syrup containing English ivy leaf might improve coughing and breathing in children and adults with different types of bronchitis. Results of trials with different extracts are only valid for the tested preparation but not for the tested plant [15]. * Ivy leaf supports healthy mucosa beginning with the nose, mouth, and throat, and continuing to the bronchial passageways and lungs. This leads to relaxation in the bronchial muscles and plausibly explains the bronchospasmolytic effect of ivy [24]. Demographic parameters were compared between the study groups by chi-squared test or analysis of variance, as appropriate. Ivy Leaf Extract. Complement Med Res 2005;12(6):328-32. Review articles are excluded from this waiver policy. Bottles), Garden of Life Elderberry Zinc Support for Adults Kids 12 and Older, mykind Organics Cough & Mucus Syrup with Ivy Leaf, Vitamin C Echinacea, No Added Sugars, 6.59 Fl Oz, Garden of Life Elderberry Zinc Immune Support for Kids, mykind Organics Kids Cough & Mucus Immune Syrup with Ivy Leaf, Vitamin C and Echinacea for Children, Alcohol Free, No Added Sugars, 3.92 fl oz, Terry Naturally Bronchial Clear Liquid - 3.4 fl oz - Soothing Lung & Upper Respiratory Function Support Supplement, Non-Drowsy, Non-Jittery - Gluten-Free - 20 Servings, Zarbee's Naturals Children's Cough Syrup* with Dark Honey Daytime & Nighttime, Grape, 4 Ounces (Pack of 2), Banyan Botanicals Bronchial Support – Organic Herbal Syrup for Children & Adults – Soothing & Comforting, Supports a Healthy Respiratory System* – 6oz. Compared with the conventional quality control method that measures the contents of hederacoside C in ivy leaf extracts, the newly developed method can provide more information about the chemical composition of ivy leaf extracts. One patient reported diarrhea after she had used EA 575® for two days, and after discontinuing of the medication, the patient had recovered. The solvent is then partially or completely evaporated to obtain a soft or dry extract. Zarbee's Naturals Children's All in One Nighttime Cough Syrup + Mucus, Throat & Nasal, Natural Grape Flavor, 4 Ounce, Prospan Cough Syrup - 100ml CHESTY Cough Relief & Mucus Relief. Both, physicians and patients described the efficacy of EA 575® comparable with acetylcysteine. The present noninterventional study was intended to gain further data on the application of a cough syrup containing ivy leaf extract EA 575® by evaluating its efficacy and safety in children and adults with symptoms of acute bronchitis. Patients themselves rated the following symptoms that were queried by the physician: 5-staged-score for coughing intensity, chest pain during coughing, dyspnoea during coughing, cough-related sleep disturbances, and possibility to cough-up mucus and 4-staged-score for number of coughing fits during daytime. This covered the indication of acute bronchitis and included the typical symptoms such as cough, sputum (phlegm) production, shortness of breath, and wheezing related to the obstruction of inflamed airways. ( You can buy English Ivy plant here: English Ivy 4 Plants -- Hardy Groundcover -- Great Bonsai ). Hedera helix. Clinical findings and subjective symptoms assessed by physicians showed a statistical significant improvement compared with that of the baseline, which was essentially comparable between the two groups. The German College of General Practitioners and Family Physicians (DEGAM) guidance describes the health-economic relevance of acute bronchitis as well [11]. Büechi S, Vögelin R, von Eiff MM, Ramos M, Melzer J. Two galenical formulations of an ivy herbal extract, syrup and cough drops, were tested for their efficacy and safety in the paediatric treatment of cough and bronchitis in two independent open, non‐interventional studies with identical design. 2020, Article ID 1910656, 7 pages, 2020. https://doi.org/10.1155/2020/1910656, 1Max Zeller Söhne AG, Seeblickstrasse 4, Romanshorn 8590, Switzerland, 2CONSULTING HMP, Brückstrasse 11, Weinheim 69469, Germany, 3Landarztpraxis Sevelen, Velturrietstrasse 5, Sevelen 9475, Switzerland. The study revealed a significant and clinically relevant improvement in patients with acute bronchitis receiving oral treatment with EA 575®. The data of all patients were analysed on an intend-to-treat basis, which had used at least one dose of the medication. English ivy leaf might cause skin irritation when taken by mouth. Soothing syrup provides relief from occasional irritation; Breathe Easy with Bronchial Soothe! Acute bronchitis affects approximately 5% of adults annually, with a higher incidence observed during winter and fall than in summer and spring [3, 4]. Concomitant diseases were mainly treated with antibiotics and other treatment (Table 4). Further, the patients were asked to keep a diary during the course of treatment, which includes following symptoms: number of coughing fits during daytime, coughing intensity, chest pain during coughing, dyspnoea during coughing, possibility to cough-up mucus, cough-related sleep disturbances, frequency of wake ups at night, and general well-being. In the current study design (noninterventional study), the physicians were totally free in their prescription decision. Zarbee'S Natura Children's Grape Flavor Cough Syrup + Mucus, 2 Ounce, Herbion Naturals Ivy Leaf Syrup with Thyme and Licorice, 5 fl oz- Helps Maintain Respiratory and Bronchial Health, Supports Healthy Mucous Membranes, Effective for Adults and Children | Pack of 3, Vicks Children's Botanicals, Day & Night Twin Pack, Elderberry Syrup to Soothe Nasal Irritation, Marshmallow Root to Soothe Cough, Ivy Leaf to Help Clear Mucus, Drug-Free 4 FL OZ Day/4 FL OZ Night, Mommy's Bliss Organic Kids Cough Syrup + Immunity Support - 4 fl oz, Nature's Life English Ivy Extract | Helps Support Respiratory & Bronchial Health | 136mg of Hedera Helix Leaf Extract (English Ivy), Vegetarian | 90ct, Zarbee's Naturals Children's Cough Syrup + Mucus with Dark Honey & Ivy Leaf, Natural Grape Flavor, 4 oz Bottles (Pack of 2), Children's Robitussin Naturals Cough Relief Honey & Ivy Leaf Syrup 8.3 oz, Zarbee's Naturals Cough & Throat Relief + Mucus Daytime Drink Mix with Dark Honey, Natural Lemon Flavor, 6 Packets, FREE 2-hour delivery on orders over $35 with Prime. EA 575® is effectively independent of the indication or concomitant disease. 24.6% of the subjects from the EA 575® group suffered from acute bronchitis caused by bacterial infection and 19.0% in the ACC group (Table 2). It is the most common disease in industrialized countries, and thus herbal expectorants enjoy a high popularity in many European countries due to their favorable risk-benefit ratio. It is important to note that the decision to treat the patient with either EA 575® or an ACC mono preparation was made before it was decided to include the patient into the noninterventional study. * Give Twice Daily Not to exceed 2 servings in 24 hours The average age was 44.3 years for the EA 575® group and 49.1 years for the ACC group. Ivy leaf extract is a traditional ingredient that has been used for centuries to support bronchial health. ENGELHARD Arzneimittel GmbH & Co. KG Herzbergstraße 3, 61138 Niederdorfelden, Germany Module 1 Common Technical Document Prospan Syrup THR 35693/0001 $16.39$16.39 ($3.21/Fl Oz) FREE Shipping. 4.1 out of 5 stars 65. Cough syrup (Prospan; Panoto-s; Athos; Abrilar) containing English ivy leaf extract is POSSIBLY SAFE when taken by mouth three times daily for 1 week. Cough and fever are the most common symptoms of acute bronchitis in children. Extraction solvent: ethanol 30 % w/w. Comparable improvement was seen for all symptoms between both groups from the entry to final visit which was statistically significant. Ivy creepers grow up to 30 meters long with a permanent green leaves and numerous aerial roots which help it affix on trees and stones. The evaluation of the individual data on symptoms was only carried out for those patients in whom the symptom was present at the beginning of the study. Coferb contains Ivy Leaf extract that relieves cough and congestion. Most of these studies have been performed as uncontrolled, open postmarketing studies, some studies in a randomized placebo-controlled design, and some in a reference-controlled design. Fortified with Lactobacillus Paracasei MCC1849, a patented probiotic from Japan. In addition, the EA 575® preparation showed to be effective in children and adults independent of the indication or concomitant disease and can therefore be used as an alternative to the synthetic ACC preparation. For dyspnoea during coughing, better improvement was seen in the EA 575® group. Ivy leaf dry extract HRS European Pharmacopoeia (EP) Reference Standard; find null-Y0001592 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. ACC mono acetylcysteine preparation (granulate, syrup, or effervescent tablet, products available in the Swiss market): The following doses are recommended according to the summary of product characteristics. Totally, 25 physicians were recruited in Switzerland who participated with 139 patients. Introduction. Ivy Syrup IVY LEAF EXTRACT 50 mg Read all of this leaflet carefully because it contains important information for you. Further, cough-associated sleeping disorders improved more in the EA 575® group. The study was conducted at 25 medical practices throughout Switzerland as prospective, open, noninterventional study. Within the 139 included patients, only 21 patients were prescribed an acetylcysteine preparation resulting in an unequal group distribution. L. Ivy leaf preparations are obtained as dry, liquid and soft extracts by putting the plant material in a solvent (such as ethanol) to dissolve compounds and form a liquid extract. Hedera helix preparations (ivy leaf extracts) are worldwide marketed for the treatment of different diseases of the respiratory tract system and include catarrh of the respiratory passages; symptomatic treatment of chronic inflammatory bronchial illnesses; and acute inflammations of the respiratory tract accompanied by coughing (HMPC Assessment) [1]. Herbion Naturals Ivy Leaf Syrup with Thyme and Licorice, 5 fl oz- Helps Maintain Respiratory and Bronchial Health, Supports Healthy Mucous Membranes, Effective for Adults and Children. Significant improvement in each of the symptoms from the entry visit to final visit (, Average values of physician`s evaluation for severity of disease and calculated BSS score at entry and final visit in both groups comparing the final visit with the entry visit. The results show that there is no evidence that the efficacy differs between both groups. Alternative & Herbal Products. At entry visit, duration of symptoms was assessed as well (Table 3). Material and Methods. The study was stopped, and the physicians were informed accordingly. Prospan syrup Ivy leaf dry extract Read all of this leaflet carefully before you start using this medicine because it contains important information for you. These effects are attributable, in particular, to the therapeutically important constituents of the ivy leaf extract, which belong to the class of triterpene saponins such as hederacoside C (Figure 1), a marker and an active ingredient of ivy leaf extract [7–10]. Maty's Organic Children's Mucus Cough Syrup, Made with Organic Honey, Thyme & Ginger - 6 fl oz. The severity of the disease started with 4.3 points in the EA 575® group and with 4.24 points in the ACC group showing a moderate status of disease. English ivy leaf extract might cause mild stomach problems.. Not enough is known about the safety of applying English ivy to the skin. There were no specifications available for the calculation of a reasonable sample size; sample size of 300 patients deemed to be sufficient based on the previous studies and practical reasons. The study results indicate that ivy leaf extract might be an effective alternative to acetylcysteine with respect to the improvement of respiratory function in children and adults at a slightly better evaluation of efficacy. Prime members enjoy FREE Delivery and exclusive access to music, movies, TV shows, original audio series, and Kindle books. The average duration for symptoms at entry visit was 2.341 days in the EA 575® group and 2.33 days in the ACC group. Viral infection-caused acute bronchitis was the most common disease at entry visit with 53.4% in the EA 575® group and 57.1% in the ACC group, followed by other acute inflammation of the respiratory diseases with 25.4% in the EA 575® group and 33.3% in the ACC group. The first patient was recruited in January 2017, and the last visit of the last patient was in March 2018. 7 children were noted in the class group 11–13 years with an average height of 137.1 cm and an average weight of 37.0 kg. Furthermore bronchial muscle cells reduce under β2-stimulating conditions the intracellular Ca2+ level. Material and Methods. Patients or their parents rated the tolerability as “very good” and “good” with 98.3% in the EA 575® group and 90.5% for the ACC group. Over the entire treatment period, there was a reduction to 1.8 points in the EA 575® group and to 2.1 points in the ACC groups corresponding to a low impairment in both groups and showing a comparable continuous improvement in both groups. The main components of ivy leaf that give it its health benefits are called saponins. Further, the severity of the disease was rated by a 7-stage-score and coughing quality (auscultation) by a 3-stage-score. Sydler Remedies Private Limited - Category: Pharma & Supplements. 22. The data used to support the findings of this study are available from the corresponding author upon request. I was prescribed ivy leaf extract for my (quite heavy) cough. PROSPANEX® Cough Syrup: 5 ml contains 35 mg Hedera helix leaves dry extract (DER 5–7.5 : 1) as active ingredient, manufactured by Engelhard Arzneimittel GmbH and Co. KG. Top subscription boxes – right to your door, © 1996-2020, Amazon.com, Inc. or its affiliates. At the beginning, BSS average was 6.5 points in the EA 575® group and 6.7 points in the group of ACC patients, respectively, showing a moderate impairment for both. Description: Cofif syrup contains IVY Leaf extract. These positive results for the herbal medication correspond to the pharmacological actions of ivy. We start with our proprietary Dark Honey Blend and add English Ivy Leaf extract and Marshmallow Root Extract to soothe irritated throats and help your child clear mucus when they are coughing. Ivy Leaf Cough Syrup With Thyme & Stevia - Herbion Naturals Ivy is solid at its base, and then it starts to crawl. We are committed to sharing findings related to COVID-19 as quickly as possible. described the mode of action stating that α-hederin inhibited the terbutaline-stimulated internalization of the β2-AR. A. Fowler, “Acute bronchitis,”, V. Benson and M. A. Marano, “Current estimates from the national health interview survey, 1995,”, J. Macfarlane, “Prospective study of the incidence, aetiology and outcome of adult lower respiratory tract illness in the community,”, T. C. Medici, M. Häcki, and M. V. Spiegel, “Spiegel MV. More Buying Choices. PROSPAN ® Cough Syrup with ivy leaf offers reliable help with the excessive formation of thick mucous and coughs associated with colds.. An exclusive extraction method and absolute precision in production ensure the quality of the dried ivy leaf extract that makes PROSPAN® such an effective and safe remedy. The same extract is contained as active ingredient in the present noninterventional study. Ivy Leaf Cough Syrup Benefits: Natural formula to reduce coughing, soothe airways and to clear mucus and phlegm or effective congestion and cough relief. In summary, the study showed that both preparations are effective and safe in the treatment of bronchitis. The following clinical findings were documented during both visits by the physicians in accordance with the Bronchitis Severity Score (BSS) [16] by a 5-stage assessment: coughing fits, sputum, rales/rhonchi, and dyspnoea during coughing. IVY leaf. Essentially, all captured data are calculated as frequency distributions and descriptive analysis (e.g., averages, medians, standard deviations, minimums, and maximums). from a wet cough; active substance: ivy leaf extract; syrup; country of production: Ukraine The present Swiss study investigated the intake of EA 575® and acetylcysteine and confirmed the results from Lang et al. And 10 children were between 14 and 17 years old with an average height of 166.1 cm and an average weight of 63.0 kg. The validated method was successfully applied to quantify all six compounds in a 30% ethanol ivy leaf extract and 13 ivy leaf extract products. With regard to duration of symptoms, no significant differences were observed between the treatment groups. Syrup: for children up to 12 years, 5 ml, three times daily, and for 12 years and older and adults, 10 ml, three times daily. English ivy exhibits antiviral, antimycotic, and anthelmintic and effects and some studies indicate that the It possesses antitussive and expectorant action that provides relief from bronchial cough and other associated respiratory afflictions. CZ and EK are the employees of Max Zeller Söhne AG. Subgroup evaluation was performed within the EA 575® group regarding indication at inclusion into the study and concomitant disease or infection. Sign up here as a reviewer to help fast-track new submissions. Ivy leaf Extract Syrup. oz. 2016-01555). The level of significance was α = 0.05. Description. There's a problem loading this menu right now. Prospan Chesty Cough Relief - Prospan Australia - Prospan … In the United States, acute bronchitis is the ninth most common illness among outpatients, as reported by physicians [9]. In the ACC group, 21 × 7.48 = 157 patient days were calculated together across all dosage forms. It is characterized by a persistent cough which can be productive or dry. After viewing product detail pages, look here to find an easy way to navigate back to pages you are interested in. A previous multicenter study showed that EA 575® exerts mucolytic action equal to acetylcysteine but with better tolerability [23]. Product Name: Cofloz Ivy Leaf Cough Syp 120ml Product Form: Syrup Pack Size: 120ml Marketed By: Abbott Laboratories (Pakistan) Ltd Generic Category: Anti-Tussive Ingredients: Ivy Leaf Extract 23. This advantage could be demonstrated by the improvement of coughing fits, sputum, rales, dyspnoea, and severity of the disease during the 7 day-treatment as the primary outcome which was expressed by the BSS. ( hederae helicis folium ) exert an expectorant which eases chest ivy leaf extract syrup inflammation... Very good the employees of Max Zeller Söhne AG recommended as a natural cough syrup - Homeopathic for! 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